Evaluation of the Anti-Hypoxia and Anti-Fatigue Effects of Ganoderma lucidum Polysaccharides

Abstract

The present study was designed to determine the anti-hypoxia and anti-fatigue effects of Ganoderma lucidum polysaccharides (Gl-PS). The anti-hypoxia effects were evaluated by survival times of mice under anoxic condition of ordinary pressure. The anti-fatigue effects were evaluated by exhaustive swimming times of mice, and some biochemical parameters related to fatigue were measured. The results showed that Gl-PS could prolong survival and exhaustive swimming times, decrease blood lactic acid (BLA) and blood urea nitrogen (BUN) contents, and increase the liver and muscle glycogen contents of mice. Gl-PS had anti-hypoxia and anti-fatigue effects.