Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H<sub>2</sub> -Receptor Antagonist-Reference-Cited by-同舟云学术

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Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H₂ -Receptor Antagonist

Published:2012-07 Issue: Volume:554-556 Page:1849-1852
ISSN:1662-8985
Container-title:Advanced Materials Research
language:
Short-container-title:AMR

Author:

Zhang Hui¹,Wu Min Fan¹,Tian Yu²,Tong Jian³,Shang Li Hong¹

Affiliation:

1. Shenyang Medical College

2. Shenyang Pharmaceutical University

3. College of Chemistry, Liaoning University

Abstract

More new phenoxypropylamines have been synthesized. All the products have been characterized by elemental analysis, 1H-NMR, 1C-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity reSuperscript textsults, we found that some of them showed significant gastric acid antisecretory activity.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

Link

https://www.scientific.net/AMR.554-556.1849.pdf

Reference3 articles.

1. Tarpanov, V.; Vlahov, R.; Penkov, M.; Krikorian, D.; Parushev, S.; Mechkarova, P.; Angelova, N.; Schunack, W. A new synthesis of roxatidine acetate [J]. Syn. Commun., 29, 15-20 (1999).

2. Hui Zhang; Bao-Yan Zhang; Qian-Yun Zhang; Dong-Mei Zhao; Jia-Mei Wang. Phenoxypro-pylamines: Synthesis and Antiulcer Evaluation [J]. Molecules, 14 (5): 1818-1824 (2009).

3. Hirota, K.; Kudo, M.; Kushikata, T.; Hashimoto, H.; Matsuki, A. Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume [J]. Can. J. Anaesth, 52(2): 166-171(2005).

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