Potential of Nanomaterials as Movers and Packers for Drug Molecules

Abstract

As the development of nanotechnology has extended to the world of biomolecules, a revolution has occurred in the design and assembly of nanomaterials for drug delivery with a significant potential to impact drug efficacy and patient outcomes. Currently a number of nanomaterials are under investigation for their suitability as sustained, controlled and targeted drug carriers. Leading edge of the rapidly developing nanosciences is the development and assessment of these nanomaterials, with specific physicochemical properties different from their larger/ bulk counterparts, as vehicles for transport of small and large drug molecules. The characteristics such as size, shape, chemical composition, surface structure and charge, aggregation and agglomeration, and solubility, can greatly influence interactions of these nanostructured systems or carriers with biomembranes and cells. The selectivity and reactivity achieved due to the very small size assigns these systems with a wide spectrum of applications. In this review, nanomaterials are considered in terms of the physical attributes or pharmaceutical effects allocated by them to the all-inclusive carrier or vehicle system (s). However we will limit our discussion to lipidic and polymeric nanomaterials, the two most commonly promoted, and safe nanosystems for delivery of both, the chemical or small molecular entities (SME) and the macromolecules including genes and siRNA.Contents of Paper