Combined Photodynamic Thermochemotherapy of Glial Tumors Controlled by MRI and Electronic Sensor

Abstract

As a result of consecutive intravenous injections of combination from 0.05 up to 1.0 ml 1.0-10 % sol Dextran-ferrite (DF), and 0.001-0.02 ml Magnevist contrast-enhansend (CE) MRI, have reduced to 4 days time of early visualization CE MRI of proliferation centres of glial tumor. Electron-touch mapping DF in a tumor and a liver have defined size of a ratio of contents DF in a tumor to contents DF in a liver ≥ 100 at which combined photodynamic magneto-thermochemotherapy, was preferable and have increased life span of rats with glioma C6 (GC6) up to 166% and at glioblastoma 101/8 (GB 101/8) up to 74%.