Recognition and Electrochemical Sensing of 8-Hydroxydeoxyguanosine with Molecularly Imprinted Poly (ethylene-co-vinyl alcohol) Thin Films

Abstract

Biosensors using the mechanisms of electrochemical, optical, mass sensitive thermometric and magnetometric have been intensively investigated [1], and molecularly imprinted polymers (MIPs) has been used as recognition elements in sensors reviewed in numerous articles [1-3]. A severe challenge for MIP sensors is detection in chemically diverse environments, such as biological fluids [4-7]. There are many biomarkers discovered in biological fluid, like cerebrospinal fluid (CSF), saliva, serum and urine. Important biomarkers such as creatinine [4], urea, and albumin [8], urine contains non-protein nitrogen metabolites, carbohydrates [9], proteins and amino acids [10]; detection of analytes must be made amid this complex chemical background.