Synthesis of 2-Chloro-4,6-Diamino-5-Cyanopyrimidine and its Amino-Substituted Derivatives

Abstract

The important pyrimidine intermediate 2-chloro-4,6-diamino-5-cyanopyrimidine was prepared by the cyclization of sodium salt of 1-amino-1-cyanamino-2,2-dicyanoethylene which was obtained from sodium dicyanamide and malononitrile via the nucleophilic addition in good yield and purity. The 4,6-diamino-5-cyanopyrimidines substituted with different amino groups could be synthesized by nucleophilic substitution reaction of amines, and they have good bactericidal activities to some funguses.