A Convenient Method for the Chlorination of P-Methoxybenzyl 2-(3-Phenylacetamido-4-Benzenesulfonylthio-2-Azetidinone-1-Yl)-3-Methyl-3-Butenate-Reference-Cited by-同舟云学术

A Convenient Method for the Chlorination of P-Methoxybenzyl 2-(3-Phenylacetamido-4-Benzenesulfonylthio-2-Azetidinone-1-Yl)-3-Methyl-3-Butenate

Published:2011-05 Issue: Volume:233-235 Page:66-69
ISSN:1662-8985
Container-title:Advanced Materials Research
language:
Short-container-title:AMR

Author:

Xing Jun De¹,Wei Wen Long¹,Chang Hong Hong¹,Li Xing¹

Affiliation:

1. Taiyuan University of Technology

Abstract

A convenient method for the chlorination of p-methoxybenzyl 2-(3- phenylacetamido-4- benzenesulfonylthio-2-azetidinone-1-yl)-3-methyl-3-butenate from penicillin G with sulfuryl chloride ( SO2Cl2) , which is subsequently converted to p-methoxybenzyl 2-(3- phenylacetamido-4- benzenesulfonylthio-2-azetidinone-1-yl)-3-chloromethyl-3-butenate, versatile intermediates for the synthesis of cephalosporin antibiotics was developed. The method has the advantage of cheap reagents, mild reaction conditions and convenient operation. The quantity and the feeding rate of the chlorination reagent can be controlled easily. The method is particularly suitable for the chlorination in an industral process.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

Link

https://www.scientific.net/AMR.233-235.66.pdf

Reference18 articles.

1. Jinxia Sun: Tianjin Chemical Industry, Vol. 16(2002), p.39 ( In Chinese).

2. Meifa Zhao: Fine Chemical Industrial Raw Materials & Intermediates, Vol. 6 (2005), p.26( In Chinese).

3. Wenmei Wang: Fine and Specialty Chemicals, Vol. 11(2003), p.19( In Chinese).

4. N. Matsumoto, H. Kawakabe, Y. Manabe: U.S. Patent 2007/0, 027, 313 (2007).

5. D. Pandurang Balwant, K. Sanjay Nivrutti, R. Padmanabhan: WO. patent 2004/039, 813 (2004).