The Cyclization of 2-Chloro Nicotinic Acid

Abstract

Studied the craft of synthesize 2-ChloroNicotinicacid, which was 3-Dimethylamino -acrolein and Eethylcyanoacetate as raw materials, synthesized 2,4-pentadienoicacid-2-cyano-5- dimethylaminoethylester, then used HCl gas to cyclize it, the product Ethyl 2-chloronicotinate was hydrolyzed to get 2-chloronicotinicacid. The effects of solvent and catalyst were discussed. The results showed that 2,4- pentadienoi cacid – 2-cyano-5-(dimethylamino) ethyl ester can be dissolved in dimethylethane at low temperature, so that it avoided the own polymerization when cyclization synthesis Ethyl 2-chloronicotinate. The yield was 91.84%. The craft was simple and had less steps and higher yield; there is the potential for industrialization