Affiliation:
1. Jiangxi Science and Technology Normal University
Abstract
As non-hydrolyzable analogs of stavudine 5’-triphosphate, β,γ-bridging oxygen-modified stavudine 5’-triphosphates (β,γ-CX2-NTPs, X = H, F, and Cl) possess potential medicinal value in the treatment of viral infections and are of substantial interest to both synthetic and medicinal chemists. Three β,γ-bridging oxygen-modified stavudine 5’-triphosphates were synthesized from stavudine 5’-phosphoropiperidate with 4,5-dicyanoimidazole (DCI) as the activator.
Publisher
Trans Tech Publications, Ltd.
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