Affiliation:
1. Jiangxi Science and Technology Normal University
Abstract
Acyclovir β,γ-methylene/dihalomethylenetriphosphates were efficiently synthesized from acyclovir phosphoropiperidate obtained via the redox condensation with 2,2′-dipyridyldisulfide/PPh3 system. Promoted by 4,5-dicyanoimidazole (DCI), the phosphoropiperidate intermediate exhibited high reactivity toward the bisphosphonates.
Publisher
Trans Tech Publications, Ltd.
Reference10 articles.
1. E. De Clercq, H.J. Field, Br. J. Pharmacol. Vol. 147 (2006), p.1.
2. H. Schaffer, V. Robert, S. Bittner, S. Gurwara, J. Med. Chem. Vol. 14 (1971), p.367.
3. L. Weinschenk, C. Meier, in: Chemical Synthesis of Nucleoside Analogues, edited by P. Merino, chapter, 5, John Wiley & Sons, Hoboken, NJ (2013).
4. Q. Sun, S. -S. Gong, J. Sun, C. -J. Wang, S. Liu, C. Ma, Tetrahedron Lett. Vol. 55 (2014), p.2114.
5. Y. Wu, V.M. Zakharova, B.A. Kashemirov, M.F. Goodman, V.K. Batra, S.H. Wilson, C.E. McKenna, J. Am. Chem. Vol. 134 (2012), p.8734.