Affiliation:
1. Jiangxi Science and Technology Normal University
Abstract
A novel and efficient method for the preparation of acyclovir diphosphate and triphosphate has been developed. Phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling with piperidine yielded acyclovir phosphoropiperidate benzyl ester intermediate in excellent yield. Acyclovir polyphosphates were synthesized in good yields by using the phosphoropiperidate/DCI system.
Publisher
Trans Tech Publications, Ltd.
Cited by
1 articles.
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