Effect of Crude Polysaccharides from Discorea bulbifera L. on the Liver in the Mice Bearing U14 Cervical Carcinoma

Abstract

To explore the effect of crude polysaccharides of Dioscorea bulbifera L. (DBLP) on liver organs in mice bearing cervical cancer, the effects of DBLP on the liver weight in vivo, sections of liver were examined. Glutamate pyruvate transaminase (GPT) and Glutamic oxalo acetic Transaminase (GOT) activites of blood serum in tumor-bearing mice were detected by the colorimetric method. Superoxide dismutase (SOD) and Glutathione reductase (GR) of hepatic tissues were also determined by means of colorimetric method. Our results showed that the liver index, GPT and GOT activities of blood serum, SOD and GR activities of hepatic tissues of DBLP groups were almost the same as that of negative groups. however, the liver index, GPT and GOT activities of blood serum were decreased in DBLP groups compared to CTX groups. And the SOD and GR activities of hepatic tissues of DBLP groups were higher than that of CTX groups. These results demonstrated that DBLP had no effect on liver organs in mice bearing cervical cancer. These data would be a foundation for the appication of DBLP in antitumor, which indicated that DBLP would be a potential antitumor drug. And the further studies, such as antioxidant, should be developed.