Studies of the Effect of Decontamination Methods on the Surface Condition of the Stoppers in Contact with Drugs-Reference-Cited by-同舟云学术

Studies of the Effect of Decontamination Methods on the Surface Condition of the Stoppers in Contact with Drugs

Published:2019-08 Issue: Volume:816 Page:260-265
ISSN:1662-9795
Container-title:Key Engineering Materials
language:
Short-container-title:KEM

Author:

Khakimullin Yu.N.¹,Simonova N.N.¹,Guzhova S.V.¹,Zakirova Larisa Yuryevna¹,Romanova N.K.¹,Yarullin R.S.¹

Affiliation:

1. Kazan National Research Technological University

Abstract

The influence of means and modes of sanitary-hygienic treatments on the surface condition of medical rubber stoppers based on butyl and halobutyl rubbers used for sealing injection and infusion drugs was investigated using the method of determining the contact wetting angle on a DCAT 21 tensiometer. It has been established that the methods used for sanitary-hygienic processing have a destructive effect on the state of the surface, accompanied by a decrease in the edge angle of wetting (an increase in the hydrophilicity of the surface of the stoppers), which significantly increases the possibility of interaction with the dissolved pharmaceutical substances of drugs.

Publisher

Trans Tech Publications, Ltd.

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

Link

https://www.scientific.net/KEM.816.260.pdf

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1. Determination of the Composition of Substances Migrating from Plugs Based on Bromo-Butyl Rubber into Infusion and Injection Preparations;Key Engineering Materials;2020-10

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