Effect of Sophora Japonica Total Flavonoids on Mouse Models of Hyperglycemia and Diabetes Model

Abstract

Objective: To investigate the effects of Sophora japonica total flavonoids hyperglycemia and diabetes in mice models. Methods: intraperitoneal injection of epinephrine, intravenous injection of freshly prepared alloxan or intravenous injection of streptozotocin, alloxan build adrenaline or hyperglycemia model streptozotocin diabetic model. Glucose values ​​were selected for each experiment> 11.1mmol / L, with a significantly more drinking, eating, and more urinary symptoms in mice 60, according to blood glucose levels were randomly divided into six groups, namely large, medium and small doses of Sophora japonica total flavonoids group, metformin group, the control group and model group. And were fed the appropriate medication, model group and the control group fed with the same volume of saline solution. Results: Sophora japonica total flavonoids can significantly reduce the adrenaline and alloxan mice with high blood sugar glucose levels, improve liver glycogen content; can significantly reduce the streptozotocin-diabetic mouse model of blood glucose levels and improve hepatic glycogen,can significantly improve the streptozotocin-induced islet cell damage. Conclusion: Sophora japonica total flavonoids mouse model of hyperglycemia and diabetes mellitus have a better hypoglycemic effect of its hypoglycemic effect and promote glycogen synthesis, reduce islet cell damage.