Synthesis, Structure and Gastric H<sup>+</sup>/K<sup>+</sup>-ATPase Inhibitory Activities of Bisabolonalone Hydrazone Carboxamides-Reference-Cited by-同舟云学术

Synthesis, Structure and Gastric H⁺/K⁺-ATPase Inhibitory Activities of Bisabolonalone Hydrazone Carboxamides

Published:2013-09 Issue: Volume:781-784 Page:1098-1101
ISSN:1662-8985
Container-title:Advanced Materials Research
language:
Short-container-title:AMR

Author:

Jin Lei¹,Chen Lei¹,Luo Hua Jun¹,Guo Zhi Yong¹,Huang Nian Yu¹,Deng Wei Qiao¹

Affiliation:

1. China Three Gorges University

Abstract

Five novel bisabolonalone hydrazone carboxamides were synthesized as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. All of the compounds possessed the better H+/K+-ATPase inhibitory activity than the commercial omeprazole with the IC50 of 18~68 μM in vitro. These compounds could be potentially use for the treatment of ulcer related diseases.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

Link

https://www.scientific.net/AMR.781-784.1098.pdf

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