Study on Biochemical Materials with Development of Hollow and Paclitaxel-Loaded Bubbles for Ultrasound Controlled Drug Release-Reference-Cited by-同舟云学术

Study on Biochemical Materials with Development of Hollow and Paclitaxel-Loaded Bubbles for Ultrasound Controlled Drug Release

Published:2013-09 Issue: Volume:771 Page:13-16
ISSN:1662-8985
Container-title:Advanced Materials Research
language:
Short-container-title:AMR

Author:

Wu Shi Chao¹,Yang Xiang Rui¹,Hou Zhen Qing¹,Jiang Qian¹,Wang Yan Ge¹

Affiliation:

1. Xiamen University

Abstract

We report a new type of biochemical materialmultifunctional paclitaxel-loaded poly lactide-lecithin (PLA-lecithin) microbubbles which has been developed with a method of ultrasonic double emulsion solvent evaporation (UDES) combined with lyophilization. Bubbles were characterized to be hollow, well dispersed andwith size of 300nm~2um. Paclitaxel loading efficiency could reach up to 12%, and bubbles with different size and different lecithin content showed varied drug release characteristics but all displayed slow-release and ultrasound controlled properties, illustrating the ultrasound responsive drug release effect of the combination of microbubbles and ultrasound.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

Link

https://www.scientific.net/AMR.771.13.pdf

Reference9 articles.

1. Unger E, Lund P, Shen D, et al. Nitrogen-filled liposome as a vascular US contrastagent: preliminary evaluation. Radiology 1992; 185: 453-456.

2. Unger E, McCreery T, Sweitzer R, et al. MRX 501: A novel ultrasound contrastagent with therapeutic properties. Acad Radiol 1998; 5(suppl 1): S247-S249.

3. K.S. Soppimath, T.M. Aminabhavi, A.R. Kulkarni, W.E. Rudzinski, Biodegradable polymeric nanoparticles as drug delivery devices, J. Control. Release 70 (1–2) (2001) 1–20.

4. Margaret A. Wheatley a, *, Flemming Forsberg b. Comparison of in vitro and in vivo acoustic response of a novel 50: 50 PLGA contrast agent. Ultrasonics 44 (2006) 360–367.

5. Wenjin Cui, 1 Jianzhong Bei, 1 Preparation and Evaluation of Poly(L-lactide-co-glycolide) (PLGA) Microbubbles as a Contrast Agent for Myocardial Contrast Echocardiography. . 2005 Wiley Periodicals, Inc.