Affiliation:
1. University of Tsukuba
2. National Insitute for Materials Science
3. Tokyo Institute of Technology
Abstract
The extent of osseous involvement, particularly spinal cord compression, is directly
correlated with patient survival. To treat metastatic spine cancer, we have developed novel
paclitaxel-loaded hydroxyapatite-alginate gels. In this study, an intraosseous spinal cancer model in
rats was used to investigate the efficacy of local treatment. Ten rats were randomized into two groups,
a local treatment group and a control group. Disease-free time and survival rate in the local treatment
group were significantly longer in this model. (p<0.05)
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
6 articles.
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