Affiliation:
1. Southwest Jiaotong University
2. Sichuan University
Abstract
We report a study involving chitosan chains immobilized on poly (ethylene
terephthalate) (PET) films by plasma and ultraviolet (UV) grafting modification. The surface structure of the modified PET is determined by means of attenuated total reflection Fourier transform infraed spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The results show that the chains of chitosan are successfully grafted on the surface of PET. Platelet adhesion evaluation in vitro is conducted to examine the blood compatibility in vitro. Scanning electron microscopy (SEM) and optical microscopy reveal that the amounts of
adhered, aggregated and morphologically changed platelets are reduced on the
chitosan-immobilized PET films. The number of platelet adhered on the modified film is
reduced by almost 48% compared to the amount of platelets on the untreated film. Our result thus shows that chitosan immobilized on the PET surface improves blood compatibility.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Reference7 articles.
1. M. K. Dewanjee, D. R. Gross, P. Zhai, S. Lanzo, H. Shim, K. Park, D. J. Schaeffer, and A. R Twardock: J. Heart Valve Disease, Vol. 8 (1999), P. 324-330.
2. K. Takahashi: Artif. Organs, Vol. 21 (1997), P. 1041-1046.
3. C. Mao, W. B. Zhao, A. P. Zhu, J. Shen and S. C. Lin: Process Biochemistry, Vol. 39 (2004), P. 1151-1157.
4. D. K. Han, S. Y. Jeong and Y. H. Kim: J. Biomed. Mater. Res. Vol. 22 (1989), P. 211-218.
5. M. Tanaka, T. Motomura, M. Kawada, T. Anzai, Y. Kasori, T. Shiroya, K. Shimura, M. Onishi and A. Mochizuki: Biomaterials, Vol. 21 (2000), P. 1471-1481.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Excimer laser chemical ammonia patterning on PET film;Journal of Materials Science: Materials in Medicine;2008-10-14