Study on the Microstructure and Biocompatibility of Inositol Hexakisphosphate-Modified Titanium Surface

Abstract

The surface topography and biocompatibility of titanium mesh treated with inositol hexakisphosphate (IP6) was studied. At high concentration of IP6, micro-grooved titanium surface with width of ~ 8 μm was formed. Then, calcium phosphate coating was deposited on the micro-grooves by a second hydrothermal treatment. Furthermore, cell culture results showed that micro-grooved surface could guide cell elongation and stretching along the grooves. Calcium phosphate modified micro-grooved titanium surface enhanced the cell viability compared with the unmodified surface. Therefore, IP6 modification may be a good candidate for improving the biocompatibility of titanium implants.