Swelling Behaviour and Water Vapour Transmission Rates of Gellan Gum/Collagen Film Containing Gatifloxacin as Dressing Materials

Abstract

In an effort to produce ideal wound dressing, gellan gum/collagen hydrogel films containing different concentrations of gatifloxacin were prepared via evaporative casting method. The films were examined in terms of physical appearances, water uptake and water vapour transmission rate (WVTR). All the films showed good physical appearances. Swelling percentages of the films were decreased, whereas WVTR values were increased as the addition of gatifloxacin was increased. Swelling percentage of gellan gum/collagen film with the lowest percentage of gatifloxacin (GG/C-GAT01) has the highest swelling ratio (2057%). Meanwhile, the WVTR value of GG/C-GAT1 has the highest WVTR value among all films which is 1245 g m-2 day-1. The formulation of GG/C films with the addition of gatifloxacin with good water absorbance and acceptable WVTRs value offered promising materials to be applied as wound dressing materials.