Modeling and Simulation of Tissue Spheroids Fusion Based on the Function Representation Approach

Abstract

Mathematical modeling for 3D bioprinting allows us to avoid widespread errors and also time and financial losses. It is necessary for such critical processes as tissue spheroids fusion and diffusion of nutrients in them. The reason is that tissue spheroids fusion is the base of the 3D bioprinting technology. In this work, we propose an approach for tissue spheroids fusion modeling considering a need to compromise between fidelity of the geometric form and viability of the whole bioconstruct.