Immune Response in Patients with Mandibular Fracture Complicated with Suppuration of a Bone Wound

Abstract

Modern clinical observations focused on the increasing complications at the open mandible fracture, which indicated about severe immune suppression in patients with this pathology. For estimation cellular immunity in a peripheral blood there were examined 25 patients in basic group (15 men, 10 women) with mandible fracture, complicated with abscess of a bone wound; control group included 20 practically healthy persons (10 men and 10 women). To assess cellular immunity in the peripheral blood were determined: absolute number of leukocytes, relative amount of lymphocytes; phagocytic activity. Determination relative number of T–lymphocytes (phenotype CD2+, СD3+) and B – lymphocytes (phenotype СD22+) was performed by method of immunofluorescence with monoclonal antibodies. In a case of mandible fracture, complicated with abscess of bone wound and leukocytosis, in the patients were reduced parameters of cellular immunity: on 40.3% – phagocytic index, on 47.7% – phagocytic number, on 43.9% – content of CD2+– and CD3+– lymphocytes. Content of null cells was increased on 76.8 %