Affiliation:
1. Sociesc-Sociedade Educacional de Santa Catarina
2. Instituto Superior Tupy - Sociedade Educacional de Santa Catarina (SOCIESC)
3. UNICAMP
Abstract
The use of bioabsorbable polymers in biomedical application has increased greatly in recent years due to their good compatibility and bio-reabsorption. To obtain a polymeric material suitable for medical applications, the obtention and characterization of copolymer poly (L-co-DL lactic acid) (PLDLA) with the addition of poly (caprolactone triol) (PCL-T) was studied. PLDLA/PCL-T membranes were prepared by solvent casting in the 100/0, 90/10 and 70/30 (w/w) compositions. The membranes were characterized by Atomic Force Microscopy (AFM), Cellular Adhesion and Energy Dispersed Spectroscopy (EDS). Using MFA it was observed that an addition of PCL-T contributes to rough morphology and greater porosity. Increased cell adhesion on 90/10 and 70/30 membranes compared to 100/0 composition and controls was observed. From these results, it was observed that PCL-T improved cellular adhesion of the PLDLA membrane when compared to membranes without PCL-T. The PLDLA/PCL-T membrane is indicated for use in medical devices which do not require long implantation time, such as support for cell culture, dressings for skin ulceration and guided regeneration in periodontics.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,Condensed Matter Physics,General Materials Science
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