Antioxidant Pathways and Chemical Mechanism of Curcumin

Abstract

Curcumin, a hydrophobic polyphenol derived from rhizome (turmeric) of the herbCurcuma longa, have been shown to exhibit antioxidant, anticarcinogenic anti-inflammatory, antimicrobial and nephroprotective activities,et al. Among these, its potent antioxidant activity is worthwhile of special attention, because oxidative stress is involved in the pathogenesis of cancer, neurodegenerative diseases,et al. This review focuses on the ways that curcumin exerts its antioxidant activity, including direct chemical reaction with free radicals, chelation with metals ions which results in oxidative stress, regulation of antioxidant-related enzyme activity and gene expression. Meanwhile the disputed chemical antioxidant mechanism is also discussed.