Mechanically Milled Co1-xFexO4 Nanocrystalline for Magnetic Hyperthermia Application

Abstract

Mechanical alloying of a mixture of Fe2O3 and CoO powders has been applied for the preparation of nanocrystalline. Utilizing a ball-to-powder mass ratio of 20, milling time of 20 hours followed by annealing at 900°C, we could obtain a nanocrystalline of high crystallinity and composed of mainly CoFe2O4 phase with presence of Fe2O3 as revealed by X-ray diffraction (XRD) measurements. Magnetic measurements using vibrating sample magnetometer (VSM) reveal high saturation magnetization for the annealed sample close to CoFe2O4 phase value. The heating efficiency of the obtained nanocrystalline is studied under an alternating magnetic field and as a function of the concentration. It was found that the nanocrystalline generate a substantial amount of heat when exposed to an alternating magnetic field. In vitro hyperthermia experiment was carried out and our result clearly demonstrates the ability of the obtained nanocrystalline to kill cancer cell through magnetic hyperthermia.