Compression Behavior Evaluation of Directly Compressible Excipients

Abstract

This work proposes to study the compression behavior of the directly compressible excipients microcrystalline cellulose (MCC). Many factors play a significant role in the compression behavior, such as the particle size and particle size distribute, flowability, particle density, porosity and so on, thus making it necessary to understand the dominant contribution of each factor. We studied the compression behavior of different types of MCC from three aspects: the physicmechanical properties, compression process and tablet mechanic characteristics of the excipients. As expected from the elastic recovery measurements, the MCC gave coherent tablets that could be handled under the chosen experimental conditions.