Affiliation:
1. Guangdong University of Technology
2. Guangdong University of Technology, Guangzhou
Abstract
Starch as the material, MBAA as the cross-linking agent, Tween60 and Span60 as the emulsifier, K2S2O8-Na2SO4 as the initiator, the cyclohexane as the oil phase and the removal rate of methyl violet as an index, crosslinked starch microspheres (CSM) was synthetized by means of reverse suspension emulsion and graft-copolymerization method through orthogonal test and single factor optimization experiment. The results showed the optimal conditions of the preparation of the crosslinked starch microspheres(CSM) were as follow: the concentration of the starch is 5%, the dosage of the MBAA, initiator and emulsifier are 0.125g, 0.5g and 0.6g, the volume ratios between the Span60 and Tween60 is 85:15, and the volume ratio between the cyclohexane and water is 4:1.
Publisher
Trans Tech Publications, Ltd.
Reference4 articles.
1. Laakso T, Sjoholml I: Pharm Sci. Vol. 76 (1987), p.935.
2. Xin Hu, Xinpu Hou: Preparation and release properties of sustained-released aceclofenac tablets. Chinese Journal of Pharmaceuticals, Vol. 28 (1997), p.406 (in Chinese).
3. Zongcheng Miao, Zhongjin Li, Deng Deng, et al. Journal of Applied Polymer Science, Vol. 115 (2010), p.487.
4. Duoxian Sun, Lan Zhao, Yiqing Chen, et al. Studies on Preparation and Swelling Behavior of Carboxymethylchitosan Ionic Complexing Microspheres, Chemistry, Vol. 5 (2004), p.359 (in Chinese).