Abstract
In the paper, synthesis of 1,2:5,6-di-O-isopropylidene-D-glucofranose (DAG) assisted by ultrasound were performed in the presence of ferric chloride as catalyst. The effects of some reaction parameters (e.g. power and frequency of ultrasound, reaction temperature, mass ratio of the reactant) on the yield were investigated. It was found that the reaction is greatly accelerated by the ultrasound in comparison to the control runs under mechanical stirring. The optimal ultrasound output power and frequency were found to be 200 W and 24 kHz at 40 °C with a 1:30 mass ratio of glucose to acetone. Under these optimal conditions, the yield of DAG reached 75.8%.
Publisher
Trans Tech Publications, Ltd.
Reference17 articles.
1. Augustyns K, Rozenski J and Aershot V A, Synthesis of 2, 4-dideoxy -β- D-erythro-hexopyranosyl nucleosides, J Org Chem. 58 (1993) 2977- 2982.
2. Limei Zhang, Weihong Zhang and Yaqing Feng, Synthesis of the derivatives of α-D-allosefuranose, Chemical Industry and Engineering. 21 (2004) 414- 417.
3. Lal B, Gidwani R M and Rupp R H, Aluminum chloride as a powerful catalyst for the preparation of O-isopropylidene and O-benzylidene derivatives of labdanes, Synthesis. 9 (1989) 711-713.
4. J Q Meng, F S Du and Y S Liu, J. Polym. Sci. Part A: Polym. Chem. 43 (2005) 752-762.
5. Singh P P, Gharia M M and Dasgupta F, Use of Ferric chloride in carbohydrate chemstry.I. a quick method for the preparation of O-iopropyledene derivatives of carbohydrate, Tetrahedron Lett. 5(1977) 439-440.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献