Preparation and Properties of Thermo-Sensitive Molecularly Imprinted Hydrogels

Abstract

In this paper, D-naproxen imprinted poly(N-isopropylacrylamide) (PNIPAAm)hydrogels was prepared by thermal polymerization method with D-naproxen as the template and N-isopropylacrylamide (NIPAAm) as functional monomer, N,N-methylene bisacrylamide (MBAA) as cross-linking agent. The thermal properties of the hydrogels were characterized by Differential Scanning Calorimetry (DSC), and the swelling behaviors, thermo-sensitivity and adsorption were studied respectively. The results showed that the D-naproxen imprinted hydrogels have good temperature-response and the LCST is about 33°C. The molecularly imprinted have good adsorbability to D-naproxen.