Predicted screening of biological activity of thiosulphonate pyrimidine derivatives-Reference-Cited by-同舟云学术

Predicted screening of biological activity of thiosulphonate pyrimidine derivatives

Published:2020-11-01 Issue:2 Volume:3 Page:53-60
ISSN:2617-7307
Container-title:Chemistry, Technology and Application of Substances
language:
Short-container-title:CTAS

Author:

Monka N. Ya., ,Stadnytska N. Ye.,Charka R. V.,Roman Y. V.,Shiyan G. B.,Khomitska G. M.,Lubenets V. I., , , , , ,

Abstract

Pyrimidine and its derivatives are important objects for chemical synthesis and development of new drugs based on them. There is a practical application of a number of substances with a pyrimidine heterocycle in medical practice. We performed a predicted screening of biological activity, cytotoxicity and toxicity in rats of some synthesized pyrimidine thiosulfonates using appropriate on-line programs. It was found that they are low-toxic substances with a wide range of biological action and a high value of probable activity, which indicates the feasibility of continuing experimental studies of their biological action, in particular anticancer. S- (4,6- dimethylpyrimidin-2-yl) benzenesulfonothioate deserves special attention for in-depth study.

Publisher

Lviv Polytechnic National University

Subject

General Medicine

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