DFT Simulation of Cortisone-Fullerenol Agents in the Therapy of Oncological Diseases-Reference-Cited by-同舟云学术

DFT Simulation of Cortisone-Fullerenol Agents in the Therapy of Oncological Diseases

Published:2022-03-31 Issue: Volume: Page:92-98
ISSN:1817-2458
Container-title:Nonlinear Phenomena in Complex Systems
language:en
Short-container-title:

Author:

Dikusar E. A.¹,Pushkarchuk A. L.²,Bezyazychnaya T. V.¹,Akishina E. A.¹,Potkin V. I.²,Soldatov A. G.¹,Kutsen S. A.³,Stepin S. G.⁴,Nizovtsev A. P.⁵,Kilin S. Ya.⁵,Babichev L. F.⁶

Affiliation:

1. Institute of Physical Organic Chemistry

2. nstitute of Physical Organic Chemistry

3. Institute for Nuclear Problems, Belarusian State University

4. Vitebsk State Order of Peoples’ Friendship Medical University

5. Institute of Physics, NAS of Belarus

6. The Joint Institute for Power and Nuclear Research – Sosny, NAS of Belarus

Abstract

In order to therapeutically destroy oncological neoplasms chemotherapy or radiotherapy is usually applied, and in isotope medicine short-lived radionuclides are injected into the tumor (59Fe, 90Y, 95Zr, 99mTc, 106Ru, 114mIn, 147;148;155Eu, 170Tm, 188Re, 210Po, 222Rn, 230U, 237Pu, 240;241Cm, 253Es). Binary (or neutron-capture) is a technology developed for a selective effect on malignant neoplasms and using drugs tropic to tumors containing nonradioactive nuclides (10B, 113Cd, 157Gd etc.). Triadic is the sequential introduction into the body of a combination of two or more separately inactive and harmless components, tropic to tumor tissues and capable of selectively accumulating in them or entering into chemical interaction with each other and destroying tumor neoplasms under the influence of certain sensitizing external influences. The aim of this work is quantum-chemical simulation of the electronic structure and analysis of the thermodynamic stability of new cortisone-fullerenol agents for the treatment of tumor neoplasms. The need for preliminary studies of modeling such objects is due to the very high labor intensity, cost and complexity of their practical production.

Publisher

Belarusian State University

Subject

Mathematical Physics,Statistical and Nonlinear Physics

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