Neonatal antibodies are detected in cord blood after vaccination of pregnant woman with the inactivated SARS-CoV-2 vaccine: A case report

Abstract

Studies evaluating the safety and efficacy of currently available vaccines for SARS-CoV-2 do not include pregnant women and newborns. Safety data for vaccinating pregnant women with the COVID-19 vaccine is urgently needed since the vaccine is the only way to protect the vulnerable population. The 33 years-old pregnant women, a healthcare worker as an obstetrician and gynecologist, was vaccinated with inactivated SARS-CoV-2 vaccine with two doses within 28 days apart as the recommended protocol, on her 29th week and 33rd week of pregnancy. The rest of the pregnancy was uneventful and she gave birth on the 38th week to a healthy infant. The infant was a healthy boy upon first evaluation. Maternal blood was sampled immediately after birth, cord blood was obtained from a neonate for the immunoglobulin testing method. COVID-19 IgG and IgM antibodies for spike antigen was reported maternal as 2.04 (reactive) and the cord blood as 1.36 (reactive in a low titration). In this case we report an infant with SARS-CoV-2 IgG and IgM antibodies detectable in cord blood after maternal vaccination with inactivated vaccine.