İkinci-Üçüncü Trimesterde Aspartat Aminotransferaz Trombosit Oranı İndeksinin Gebeliğin İntrahepatik Kolestazı Öngörmesi ve İndeksin Yenidoğan Yoğun Bakım Gereksinimi ile İlişkisi: Üçüncü Basamak Bir Hastaneden Vaka Kontrol Çalışması

Abstract

Aim: To evaluate the aspartate aminotransferase platelet ratio index (APRI) score in the prediction of intrahepatic cholestasis (ICP) in the second-third trimester of pregnancy. Material and Methods: The patient group (n=40) and control group (n=70) diagnosed with ICP who applied to the hospital Perinatology clinic between 2021-2022 were included in this study. Laboratory tests of both groups were analyzed retrospectively. Age, gravida, parity, body mass index, third trimester laboratory tests and first trimester aspartate aminotransferase (AST)/platelet count ratio [AST - platelet ratio index (APRI) score] APRI scores were compared between the two groups. The relationship between APRI score index and neonatal outcomes was evaluated in the study group.In the study, the cut-off value of the APRI score was determined for predicting ICP in second-third trimester in pregnant women. Results: Patients with ICP had significantly higher APRI scores compared with controls (p