POPYMORPHISM OF IMMUNE RESPONSE GENES AND LUNG CANCER RISK IN NON-SMOKING RESIDENTS OF KUZBASS-Reference-Cited by-同舟云学术

POPYMORPHISM OF IMMUNE RESPONSE GENES AND LUNG CANCER RISK IN NON-SMOKING RESIDENTS OF KUZBASS

Published:2023-02-16 Issue: Volume: Page:
ISSN:
Container-title:Proceedings of the 1st International Congress "The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies"
language:
Short-container-title:

Author:

Buslaev V.Yu.,Torgunakova A.V.,Milentyeva Irina¹^ORCID,Dyshlyuk Lyubov¹^ORCID,Minina V.I.

Affiliation:

1. Kemerovo State University

Abstract

Lung cancer (LC) is leading oncological pathology, posing a serious threat for patient’s lives. Accordingly to World Health Organization (WHO) 2,1 million of new cases and 1,8 of deaths are annually registered. It was accumulated a lot of information about significant influence of smoking on increased risk of LC development. 80-90% of patients with LC are namely smokers. However at present time it was registered increased level of mortality from this pathology among non-smoking patients [1]. LC formation in non-smoking individuals can occur due to environmental pollution by industrial and household cancerogens and also because of molecular and genetical and cytogenetical dissimilarities. Since LC development can be associated with anomalous immunological response, immune genes can be considered as potential biological markers [2]. Objective: To assess the influence of polymorphic variants of innate immunity genes on LC development in non-smoking patients.

Publisher

Kemerovo State University

Reference6 articles.

1. Pelosof L. Proportion of never-smoker non-small lung cancer patients at three diverse institutions / L. Pelosof.-J Natl Cancer Inst, 2017.- p.295., Pelosof L. Proportion of never-smoker non-small lung cancer patients at three diverse institutions / L. Pelosof.-J Natl Cancer Inst, 2017.-p.295.

2. Kim H. Earlier-phased cancer immunity cycle strongly influences cancer immunity in operable never smoker lung adenocarcinoma / H.Kim.- iScience, 2020.-p.101386., Kim H. Earlier-phased cancer immunity cycle strongly influences cancer im munity in operable never smoker lung adenocarcinoma / H.Kim.- iScience, 2020.-p.101386

3. Tan Q. Interleukin promotes lung adenocarcinoma growth and invasion through promoting glycolysis via p38 pathway / Q.Tan.– Journal of Inflammation Research, 2021.- p.6491, Tan Q. Interleukin promotes lung adenocarcinoma growth and invasion through promoting glycolysis via p38 pathway / Q.Tan.– Journal of Inflammation Research, 2021.-p.6491

4. Eaton K. Inflammatory gene polymorphisms in lung cancer suspectibility / K.Eaton.– J Thorac Oncol, 2018.-p.649., Eaton K. Inflammatory gene polymorphisms in lung cancer suspectibility / K.Eaton.– J Thorac Oncol, 2018.-p.649.

5. Shibata A. Asssociation of IL-1β rs16944 polymorphism with acute encephalopathy with biphasic seiruzes and late reduced diffusion is opposite to that of febrile seiruzes / A.Shibata.– Front Neurol, 2022.-p.8911721., Shibata A. Asssociation of IL-1β rs16944 polymorphism with acute encephalopathy with biphasic seiruzes and late reduced diffusion is opposite to that of febrile seiruzes / A.Shibata.– Front Neurol, 2022.-p.8911721.