Author:
Cydenova I. A.,Cyganov M. M.,Ibragimova M. K.,Nushtaeva A. A.,Litvyakov N. V.
Abstract
In 25% of patients with breast cancer, tumor cells after neoadjuvant chemotherapy (NAHT)
leave the state of replicative aging and form macrometastases. In patients with breast cancer, it was
shown that the exit from replicative aging with metastasis is observed only in those patients in
whose tumor WNT signaling is ectopically activated due to amplification of activator genes and
deletions of negative regulators of this signaling pathway.
Purpose: in a direct experiment on cell cultures differing in ectopic activation of WNT
signaling due to CNA (Copy Number Aberration) WNT signaling genes, to study the ability of
tumor cells to exit replicative senescence after exposure to chemotherapy drugs.
Publisher
Kemerovo State University