Immunomodulatory effect of ashwagandha (Withania somnifera(L.) Dunal) and its impact on COVID-19-Reference-Cited by-同舟云学术

Immunomodulatory effect of ashwagandha (Withania somnifera(L.) Dunal) and its impact on COVID-19

Published:2024-04-02 Issue: Volume: Page:46-57
ISSN:2308-4057
Container-title:Foods and Raw Materials
language:en
Short-container-title:

Author:

Pushpakaran Arun M. K.¹^ORCID,Singh Jyoti¹^ORCID,Rasane Prasad¹^ORCID,Kaur Sawinder¹^ORCID,Kaur Jaspreet¹^ORCID,Kaur Jasjit¹^ORCID,Kumar Mukul¹^ORCID,Assouguem Amine²^ORCID

Affiliation:

1. Lovely Professional University

2. Sidi Mohamed Ben Abdellah University

Abstract

Ashwagandha (Withania somnifera(L.) Dunal) is an Ayurvedic medicinal herb that has been known for its therapeutic properties for millennia. Ashwagandha contains several bioactive compounds, including withanolides, alkaloids, and saponins. They make ashwagandha a potent adaptogen and a versatile herb that can maintain optimal health and overall well-being. Ashwagandha reduces stress and anxiety, as well as boosts the immune system. Its anti-inflammatory properties treat arthritis, asthma, diabetes, and inflammatory bowel disease. Ashwagandha produces an immunomodulatory effect on natural killer cells, lymphocytes, and leukemia cells. It enhances the activity of natural killer cells, increases lymphocyte function, and induces apoptosis in leukemia cells. However, its mechanism of action still remains understudied. Ashwagandha has an impact on COVID-19: phytochemical withanone blocks or weakens the interaction between S-protein and Angiotensin-converting enzyme 2. Withanoside V and somniferine inhibit viral transcription and replication caused by SARSCoV-2 Mpro. This review explores the potential utilization of ashwagandha in the food industry, i.e., its safety and toxicity, as well as the mechanism behind its immunomodulatory effect.

Publisher

Kemerovo State University

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