Mesenchymal Stem Cells in Regenerative Medicine for Musculoskeletal Diseases: Bench, Bedside, and Industry-Reference-Cited by-同舟云学术

Mesenchymal Stem Cells in Regenerative Medicine for Musculoskeletal Diseases: Bench, Bedside, and Industry

Published:2014-05 Issue:4-5 Volume:23 Page:505-512
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Wei Chih-Chang¹,Lin Andrew Boyd²,Hung Shih-Chieh¹³⁴⁵⁶

Affiliation:

1. Stem Cell Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

2. Department of Biology, Case Western Reserve University, Cleveland, OH, USA

3. Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan

4. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

5. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

6. Institute of Pharmacology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

Abstract

Human bone marrow-derived mesenchymal stem cells (MSCs) can self-renew and differentiate into osteoblasts, chondrocytes, and adipocytes. MSCs have effectively emerged as a promising tool for clinical applications, specifically in musculoskeletal diseases. This article reviews the status of preclinical animal studies, clinical trials, and the efforts of the industry in using MSCs to treat musculoskeletal diseases such as bone fractures, bone defects, focal chondral lesions, osteoarthritis, spinal diseases, and tendon injuries. We also discuss the current problems encountered and potential of using MSCs in future clinical studies.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.3727/096368914X678328

Reference81 articles.

1. The role of Osteocel Plus as a fusion substrate in minimally invasive instrumented transforaminal lumbar interbody fusion

2. Mesenchymal stem cell therapy: Two steps forward, one step back

3. Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches

4. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells

5. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo

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