The Potential Roles of EZH2 in Regenerative Medicine-Reference-Cited by-同舟云学术

The Potential Roles of EZH2 in Regenerative Medicine

Published:2015-03 Issue:3 Volume:24 Page:313-317
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Chou Ruey-Hwang¹²,Chiu Lian³,Yu Yung-Luen¹²,Shyu Woei-Cherng⁴⁵

Affiliation:

1. Graduate Institute of Cancer Biology, Center for Molecular Medicine, China Medical University, Taichung, Taiwan

2. Department of Biotechnology, Asia University, Taichung, Taiwan

3. Department of Nursing, College of Medicine and Nursing, Hungkuang University, Taichung, Taiwan

4. Center for Neuropsychiatry and Translational Medicine Research Center, China Medical University and Hospital, Taichung, Taiwan

5. Graduate Institute of Immunology, China Medical University, Taichung, Taiwan

Abstract

Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2, serves as a histone methyltransferase toward histone H3K27 trimethylation and also recruits DNA methyltransferases to regulate gene expression and chromatin structure. Accumulating evidence indicates the critical roles of EZH2 in stem cell maintenance and cell fate decision in differentiation into specific cell lineages. In this article, we review the updated progress in the field and the potential application of EZH2 in regenerative medicine including nervous system, muscle, pancreas, and dental pulp regeneration.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.3727/096368915X686823

Reference35 articles.

1. TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy

2. Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

3. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

4. Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus

5. Myocyte Enhancer Factor-2 Interacting Transcriptional Repressor (MITR) Is a Switch That Promotes Osteogenesis and Inhibits Adipogenesis of Mesenchymal Stem Cells by Inactivating Peroxisome Proliferator-activated Receptor γ-2

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