Stem Cell Applications in Regenerative Medicine for Neurological Disorders

Author:

Liu Shih-Ping12,Fu Ru-Huei13,Huang Shyh-Jer4,Huang Yu-Chuen56,Chen Shih-Yin56,Chang Cheng-Hsuan2,Liu Chia-Hui3,Tsai Chang-Hai6,Shyu Woei-Cherng13,Lin Shinn-Zong137

Affiliation:

1. Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan, ROC

2. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, ROC

3. Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, ROC

4. Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC

5. Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC

6. Graduate Institute of Chinese Medical Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC

7. Department of Neurosurgery, China Medical University Beigang Hospital, Yunlin, Taiwan, ROC

Abstract

Stem cells are capable of self-renewal and differentiation into a wide range of cell types with multiple clinical and therapeutic applications. Stem cells are providing hope for many diseases that currently lack effective therapeutic methods, including stroke, amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease. Embryonic stem (ES) cells were originally targeted for differentiation into functional dopamine neurons for cell therapy. Today, induced pluripotent stem (iPS) cells are being tested for such purposes as generating functional dopamine neurons and treating a rat model of Parkinson's disease. In addition, neural stem cell and mesenchymal stem cells are also being used in neurodegenerative disorder therapies for stroke and Parkinson's disease. Although stem cell therapy is still in its infancy, it will likely become a powerful tool for many diseases that currently do not have effective therapeutic approaches. In this article, we discuss current research on the potential application of neural stem cells, mesenchymal stem cells, ES cells, and iPS cells to neurodegenerative disorders.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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