Consensus of Clinical Neurorestorative Progress in Patients with Complete Chronic Spinal Cord Injury

Author:

Huang Hongyun1,Sun Tiansheng2,Chen Lin3,Moviglia Gustavo4,Chernykh Elena5,Von Wild Klaus6,Deda Haluk7,Kang Kyung-Sun8,Kumar Anand9,Jeon Sang Ryong10,Zhang Shaocheng11,Brunelli Giorgio12,Bohbot Albert13,Soler Maria Dolors14,Li Jianjun15,Cristante Alexandre Fogaça16,Xi Haitao17,Onose Gelu18,Kern Helmut19,Carraro Ugo20,Saberi Hooshang21,Sharma Hari Shanker22,Sharma Alok23,He Xijing24,Muresanu Dafin25,Feng Shiqing26,Otom Ali27,Wang Dajue28,Iwatsu Koichi29,Lu Jike30,Al-Zoubi Adeeb31

Affiliation:

1. Center of Neurorestoratology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China

2. Department of Orthopedics, Beijing Army General Hospital, Beijing, China

3. Medical Center, Tsinghua University, Beijing, China

4. Centro de Investigación en Ingeniería de Tejidos y Terapia Celular, Universidad Maimónides, Buenos Aires, Argentina

5. Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Institute of Traumatology and Orthopedics, Novosibirsk, Russia

6. Medical Faculty, Westfälische Wilhelms University, Münster, North Rhine-Westphalia, Germany

7. Department of Neurosurgery and Neurology, Akay Hospital, Ankara, Turkey

8. Adult Stem Cell Research Center, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Korea

9. Department of Stem Cells, Lifeline Institute of Regenerative Medicine, Rajiv Gandhi Salai, Perungudi, Chennai, India

10. Department of Neurological Surgery, ASAN Medical Center, University of Ulsan College of Medicine, Seoul, Korea

11. Department of Orthopedics, Changhai Hospital, Shanghai, China

12. Fondazione Midollo Spinale, Brescia, Italy

13. Laboratoire de Recherches sur le LASERPONCTURE, Espace Minerve, France

14. Hospital de Neurorehabilitació, Institut Guttmann, Camí Can Ruti s/n. Barcelona, Spain

15. Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center, Beijing, China

16. Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil

17. Department of Neurorestoratology, Jingdong Zhongmei Hospital, Yanjiao, Beijing East, China

18. The Teaching Emergency Hospital Bagdasar-Arseni (TEHBA), Bucharest, Romania

19. Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Department of Physical Medicine and Rehabilitation, Wilhelminenspital Wien, Austria

20. Laboratory of Translational Myology, Department of Biomedical Sciences, University of Padua, Italy

21. Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran

22. Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Sweden

23. Department of Neurosurgery, LTMG Hospital and LTM Medical College, Mumbai, India

24. Second Department of Orthopedics, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China

25. Department of Neurosciences, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania

26. Orthopaedic Department of General Hospital of Tianjin Medical University, Tianjin, China

27. Spinal Unit, King Hussein Medical Centre, Amman, Jordan

28. Midlands Centre for Spinal Injuries, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK

29. Department of Neurosurgery, Osaka University Medical School, Japan

30. Department of Orthopaedic Surgery, Tarre Hospital, NSW, Australia

31. Department of Surgery, University of Illinois College of Medicine, Peoria, IL, USA

Abstract

Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, “nothing can be done.” The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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