A Wnt Pathway Activator Induces Apoptosis and Cell Death in Mouse Monocytic Leukemia Cells-Reference-Cited by-同舟云学术

A Wnt Pathway Activator Induces Apoptosis and Cell Death in Mouse Monocytic Leukemia Cells

Published:2017-04-14 Issue:4 Volume:25 Page:479-483
ISSN:0965-0407
Container-title:Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
language:en
Short-container-title:oncol res

Author:

Kato Yoshiro¹,Naiki Yoshikazu²,Komatsu Takayuki²,Takahashi Kazuko²,Nakamura Jiro¹,Koide Naoki²

Affiliation:

1. Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

2. Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Abstract

A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in the concentration of 1‐10 μM. The Wnt agonist did not show inhibition of GSK-3β activity but induced β-catenin accumulation in the nucleus. The Wnt agonist showed caspase-independent cell death, but no further involvement in cell death ER stress signaling. Here we discuss the possible mechanism of Wnt agonist-induced apoptotic cell death in RAW 264.7 cells.

Publisher

Cognizant, LLC

Subject

Cancer Research,Oncology,General Medicine

Reference9 articles.

1. Modulation of Wnt/β-catenin signaling pathway by bioactive food components;Carcinogenesis,2012

2. Wnt/β-catenin signaling and disease;Cell,2012

3. Endometrial carcinoma: Molecular alterations involved in tumor development and progression;Oncogene,2013

4. Wnt signaling in lip and palate development;Front Oral Biol.,2012

5. Gamma interferon-induced nitric oxide production in mouse CD5+ B1-like cell line and its association with apoptotic cell death;Microbiol Immunol.,2003

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