miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis-Reference-Cited by-同舟云学术

miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis

Published:2017-07-05 Issue:6 Volume:25 Page:1009-1019
ISSN:0965-0407
Container-title:Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
language:en
Short-container-title:oncol res

Author:

Jiang Zhenfeng¹,Yao Lifen²,Ma Hongge²,Xu Panpan²,Li Zhiyan²,Guo Mian³,Chen Jianhang¹,Bao Hongbo⁴,Qiao Shupei⁵,Zhao Yufang⁵,Shen Jia⁶,Zhu Minwei¹,Meyers Carolyn⁷,Ma Guizhen⁸,Xie Chuncheng¹,Liu Li¹,Wang Haiyang¹,Zhang Wang¹,Dong Qi²,Shen Hong¹,Lin Zhiguo¹

Affiliation:

1. Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China

2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China

3. Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China

4. Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, P.R. China

5. Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, P.R. China

6. Orthopedic Hospital Research Center, University of California, Los Angeles, CA, USA

7. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

8. Department of Operating Room, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China

Abstract

Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214 expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of miR-214. These findings demonstrate that miR-214 could inhibit cell proliferation and migration through the regulation of pyroptosis intermediated by caspase 1 in glioma U87 and T98G cells and may suggest a novel therapeutic for the intervention of glioma.

Publisher

Cognizant, LLC

Subject

Cancer Research,Oncology,General Medicine

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