Neovascularization Induced by Autologous Bone Marrow Cell Implantation in Peripheral Arterial Disease-Reference-Cited by-同舟云学术

Neovascularization Induced by Autologous Bone Marrow Cell Implantation in Peripheral Arterial Disease

Published:2002-11 Issue:8 Volume:11 Page:747-752
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Esato Kensuke¹,Hamano Kimikazu¹,Li Tao-Sheng¹,Furutani Akira¹,Seyama Atsushi¹,Takenaka Hiroaki¹,Zempo Nobuya¹

Affiliation:

1. Division of Cardiovascular Surgery, Department of Bioregulation, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, Japan 755-8505

Abstract

Neovascularization has recently been used as a new treatment for severe ischemic disease. We tried to induce therapeutic neovascularization by autologous bone marrow cell implantation (BMCI) in eight selected patients with chronic peripheral arterial disease (PAD), in whom traditional treatments had failed. Improvement of subjective symptoms was seen in seven patients after treatment. Of three limbs with toe or finger ulceration, complete healing was achieved in two, while the other one became less severe after treatment. No relative toxicity was observed in any of the patients. BMCI might be a feasible treatment for selected patients with chronic PAD.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.3727/000000002783985242

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