Impact of residence on the association between benzo[a]pyrene-DNA adduct levels and CYP1B1 gene polymorphisms in breast cancer patients

Abstract

Globally, breast cancer is the primary cause of cancer-related death, and rising incidence rates are anticipated. Im¬proving illness prevention and treatment strategies requires a better understanding of the interactions occurring be¬tween genetic variables, environmental exposures, and disease pathogenesis. This study investigated the impact of residence on the association between benzo[a]pyrene-DNA adduct levels and CYP1B1 gene polymorphisms in breast cancer patients. In brief, 58 female breast cancer patients in Babylon, Iraq were recruited as subjects of this cross-sectional study. We gathered clinical information (including residency, age, age at diagnosis, and haematological markers), and by using molecular and biochemical methods, the CYP1B1 polymorphisms and the benzo[a]pyrene-DNA adduct levels were assessed. Among the different types of breast cancer, there was no apparent association between the residence and CYP1B1 polymorphisms. However, the amounts of benzo[a]pyrene-DNA adduct varied according to where a patient lived, with urban residents showing higher concentrations than rural residents. Benzo[a]pyrene-DNA adduct levels were shown to be correlated with specific polymorphisms in the CYP1B1 gene. Our study highlights the intricate connections between environmental exposures, genetic variables, and place of res¬idency in the aetiology of breast cancer. Variations in quantities of benzo[a]pyrene-DNA adducts imply possible func¬tions for environmental carcinogens, although no substantial correlation was found between genetic polymorphisms and the place of residence.