Abstract
Preeclampsia is a hypertensive disease that occurs during pregnancy in 3 to 8% of pregnancies worldwide. This disease causes significant maternal and perinatal morbidity and mortality. This article attempts to understand the pathophysiological mechanism of preeclampsia, which appears to result from a complex interaction between maternal and fetal factors and affects multiple organ systems. A central role in pre-eclampsia appears to be abnormal placentation with subsequent excess of anti-angiogenic factors and malabsorption. Further studies are needed to elucidate the pathophysiology of preeclampsia to better understand the disease, more appropriate treatment, and reduce maternal and neonatal morbidity and mortality.
Reference25 articles.
1. 1. Christopher W. Ives, Rachel Sinkey, Indranee Rajapreyar, Alan T.N. Tita, Suzanne Oparil, (2020). Preeclampsia-Pathophysiology and Clinical Presentations. JACC State-of-the-Art Review.
2. 2. Jim B, Karumanchi SA, (2017). Preeclampsia: pathogenesis, prevention, and long-term complications. Semin Nephrol 2017;37:386-97.
3. 3. Adriane Burgess, Wendy McDowell, Stacie Ebersold, (2019). Lactation and Postpartum Blood Pressure in Women With Preeclampsia. Wolters Kluwer Health.
4. Prediction of preeclampsia;Myatt;Semin Perinatol,1999
5. 5. Sarosh Rana, Elizabeth Lemoine, Joey P. Granger, S. Ananth Karumanchi (2019). Preeclampsia Pathophysiology, Challenges, and Perspectives.