Carbonic Nano-Structural Grafts - Innovation Product for Traumatology and Orthopaedics.Part 1: Experimental Study Results

Abstract

Study of the general organism response to carbonic nano-structural grafts, their osteoinductive properties, possibilities of bone defects substitution and acceleration of the distraction regenerate formation was performed. Four series of experiments were performed on 69 animals (Chinchilla rabbits and adult mongrel dogs). Laboratory and roentgenologic data showed that study grafts possessed pronounced osteoconductive properties, were not toxic and did not cause rejection response. Their application ensured the formation of strong osteo-carbonic block at the interface bone-implant. Distraction regenerate achieved required strength in 37 days after carbonic graft implantation into the bed formed in the regenerate. That enabled to discontinue external fixation with the apparatus.