Author:
Sanabria-Rios David,Alequin-Torres Denisse,Jesus Alenis,Cortes Giovanni,Carballeira Nestor,Jauregui-Matos Victorio
Abstract
Methicillin-resistant Staphylococcus aureus is a pathogen responsible for skin and wound infections, pneumonia, and bloodstream infections. Serious attention is needed because Methicillin-resistant S. aureus is also resistant to many other commonly used antibiotics. This study explores the potential of vinyl halogenated fatty acids as antibacterial agents. Specifically, the total synthesis of vinyl halogenated fatty acids was performed to investigate their antibacterial activity against clinical isolates of methicillin-resistant S. aureus. The novel synthesis of the vinyl halogenated fatty acids was carried out by treating either 2-dodecynoic acid or 2-hexadecynoic acid with an allyl halide and 5 mol% of bis(benzonitrile)palladium (II) chloride as catalyst. Our results demonstrate that vinyl halogenated fatty acids displayed significant antibacterial activity against clinical isolates of methicillin-resistant S. aureus and low cytotoxicity against eukaryotic Vero Cells. Moreover, it was demonstrated that vinyl brominated fatty acids could disrupt the S. aureus plasma membrane and inhibit the expression of the norB gene.
Publisher
Knowledge Enterprise Journals
Subject
History and Philosophy of Science,General Medicine,Developmental and Educational Psychology,Education,Experimental and Cognitive Psychology,General Medicine,Speech and Hearing,Gastroenterology,Otorhinolaryngology,Strategy and Management,General Economics, Econometrics and Finance,Business and International Management,Marketing,Energy Engineering and Power Technology,Renewable Energy, Sustainability and the Environment,Health Informatics,Computer Science (miscellaneous),Speech and Hearing,Otorhinolaryngology,Otorhinolaryngology,Literature and Literary Theory,Pediatrics,Developmental and Educational Psychology,Social Psychology
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献