De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

Author:

Kang Johnthomas,Huddleston Stephen J.,Fraser Joanne M.,Khoruts Alexander

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Reference63 articles.

1. Thymus and autoimmunity: production of CD25+CD4+naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance;Itoh;J. Immunol.,1999

2. Thymic selection of CD4+CD25+regulatory T cells induced by an agonist self-peptide;Jordan;Nat. Immunol.,2001

3. Developmental regulation of Foxp3 expression during ontogeny;Fontenot;J. Exp. Med.,2005

4. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells;Bensinger;J. Exp. Med.,2001

5. Origin and T cell receptor diversity of Foxp3+CD4+CD25+T cells;Pacholczyk;Immunity,2006

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