Early descriptions of acromegaly and gigantism and their historical evolution as clinical entities

Author:

Mammis Antonios,Eloy Jean Anderson,Liu James K.

Abstract

Giants have been a subject of fascination throughout history. Whereas descriptions of giants have existed in the lay literature for millennia, the first attempt at a medical description was published by Johannes Wier in 1567. However, it was Pierre Marie, in 1886, who established the term “acromegaly” for the first time and established a distinct clinical diagnosis with clear clinical descriptions in 2 patients with the characteristic presentation. Multiple autopsy findings revealed a consistent correlation between acromegaly and pituitary enlargement. In 1909, Harvey Cushing postulated a “hormone of growth” as the underlying pathophysiological trigger involved in pituitary hypersecretion in patients with acromegaly. This theory was supported by his observations of clinical remission in patients with acromegaly in whom he had performed hypophysectomy. In this paper, the authors present some of the early accounts of acromegaly and gigantism, and describe its historical evolution as a medical and surgical entity.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

Neurology (clinical),General Medicine,Surgery

Reference48 articles.

1. Alibert JLM: Monographie Des Dermatoses V2: Ou Precis Theorique et Pratique Des Maladies de la Peau Paris, Germer Bailliere, 1835. 477

2. Weitere Beiträge zur Akromegaliefrage

3. The mechanism of pancreatic secretion

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