Author:
Shaw Cheng-Mei,Sumi S. Mark,Alvord Ellsworth C.,Gerdes Arthur J.,Spence Alexander,Parker Robert G.
Abstract
✓ Various modes of therapy, alone or in combination, have had little effect in improving the survival of patients with glioblastoma multiforme. Recently, in a pilot study, 34 patients with glioblastoma were treated by fast-neutron-beam irradiation of the whole brain. Following treatment, the patients became steroid-dependent and pursued a gradual downhill course with increasing obtundation. Although there was no improvement in the length or quality of survival of these patients, neuropathological studies in the 13 patients who came to autopsy showed the following: 1) extensive coagulative necrosis of much of the tumor mass; 2) dense infiltration by collagenous connective tissue; 3) minimal phagocytic reaction; 4) marked reduction in the amount of viable tumor; 5) abnormal astrocytic proliferation, which may represent either astrocytoma or a radiation-induced bizarre gliosis; and 6) areas of gliosis and white matter degeneration in the brain stem, remote from the tumor site. These observations suggest that continued efforts to further refine this mode of therapy for glioblastoma are warranted.
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献